LIVEHIV Cohort

The LIVEr disease in HIV (LIVEHIV Cohort) follows a group of HIV infected patients from the Chronic Viral Illness Service at McGill University Health Centre. The primary objective of this study is to define frequency and risk factors of fatty liver and liver fibrosis in HIV infection. The principal investigator (Dr G. Sebastiani) is a hepatologist and expert on non-invasive diagnostic tools in liver disease. We have enrolled over 1000 participants. Participants undergo a special ultrasound, named Fibroscan, which can quantify fat in the liver, as well as liver fibrosis, without the need of the invasive liver biopsy. The LIVEHIV is the first Cohort specifically designed to study fatty liver in people living with HIV. The data collected demonstrate that fatty liver is an extremely frequent disease in this setting, with a prevalence which is double that of the general Canadian population.

Original research articles

  1. Benmassaoud A, Ghali P, Cox J, Wong P, Szabo J, Deschenes M, Osikowicz M, Lebouche B, Klein MB, Sebastiani G. Screening for nonalcoholic steatohepatitis by using cytokeratin 18 and transient elastography in HIV mono-infection. PLoS One (IF: 2.766) 2018, Jan 30;13(1):e0191985. doi: 10.1371/journal.pone.0191985.
  2. Pembroke T, Deschenes M, Lebouché B, Benmassaoud A, Sewitch M, Ghali P, Wong P, Halme A, Vuille-Lessard E, Pexos C, Klein MB, Sebastiani G. Hepatic steatosis progresses faster in HIV mono-infected than HIV/HCV coinfected patients and is associated with liver fibrosis. J Hepatol (IF: 14.911) 2017;67:801-808. doi: 10.1016/j.hep.2017.05.11. (Selected for the editor’s choice newsletter (October 2017) of J Hepatol.
  3. Pembroke T, Sebastiani G. Hepatic steatosis, hepatitis C, and human immunodeficiency viruses: A complex interplay. Hepatology 2017;66:673-674.
  4. Vuille-Lessard E, Lebouché B, Lennox L, Routy JP, Costiniuk C, Pexos C, Giannakis A, Szabo J, Klein MB, Sebastiani G. Nonalcoholic Fatty Liver Disease Diagnosed by Transient Elastography with Controlled Attenuation Parameter in Unselected HIV Mono-Infected Patients. AIDS (IF: 4.914) 2016 Sep 6.
  5. Sebastiani G, Rollet-Kurhajec KC, Pexos C, Gilmore N, Klein MB. Incidence and predictors of hepatic steatosis and fibrosis by serum biomarkers in a large cohort of human immunodeficiency virus mono-infected patients. Open Forum Infect Dis (IF: 3.240) 2015;2:ofv015. doi: 10.1093/ofid/ofv015.

Submitted Refereed Articles

  1. Benmassaoud A, Nitulescu R, Pembroke T, Halme AS, Ghali P, Deschenes M, Wong P, Klein MB, Sebastiani G. Occult cirrhosis in HIV-infected persons is associated with liver-related events while being under-monitored. Submitted to Clin Infect Dis (IF: 9.117).

PUBLISHED BOOK CHAPTERS

  1. Pembroke T, Sebastiani G. “Non-invasive serum markers of fibrosis”. Diagnostic Methods for Cirrhosis and Portal Hypertension- An update in the era of non-invasive tests. Editors: Annalisa Berzigotti, Jaimie Bosch. Published by Springer. 2017, in press.

PUBLISHED ABSTRACTS

  1. Cocciolillo S, Osikowicz M, Saeed S, Deschenes M, Wong P, Ghali P, Lebouche B, Klein M, Sebastiani G. Vitamin E Is an Effective Treatment for Nash in HIV Mono-Infected Patients: The CTN-PT 024 Trial. American Association for the Study of Liver Diseases (AASLD), San Francisco, USA, conference date: 2018/11
  2. Merchante N, Palumbo CS, Mazzola G, Macias J, Téllez F, Wong P, Ghali MP, Rivero-Juárez A, Klein M, Ríos-Villegas MJ, Petta S, De Ledinghen V and Sebastiani G. Noninvasive Prediction of Esophageal Varices By Liver Stiffness Measurement and Platelet Count in HIV+ Patients with Liver Cirrhosis: Multicenter Validation of Baveno VI Criteria. American Association for the Study of Liver Diseases (AASLD), San Francisco, USA, conference date: 2018/11
  3. Cocciolillo S, Osikowicz M, Lebouche B, Szabo J, Klein M, Sebastiani G for the LIVEHIV Study Group. Vitamin E as a treatment for fatty liver in HIV mono-infected patients: the CTNPT 024 study. 27th Annual Canadian Conference on HIV/AIDS Research (CAHR 2018), Vancouver BC, Canada, conference date: 2018/04
  4. Cocciolillo S, Osikowicz M, Pembroke T, Guaraldi G, Ghali P, Klein M, Sebastiani G. Application of the guidelines for monitoring nonalcoholic fatty liver disease in HIV mono-infected patients: insights from the LIVEHIV Cohort. 27th Annual Canadian Conference on HIV/AIDS Research (CAHR 2018), Vancouver BC, Canada, conference date: 2018/04
  5. Palumbo CS, Benmasaoud A, Deschenes M, Wong P, Klein M, Ghali P, Sebastiani G. HIV-Infected Persons with Liver Disease Receive Inadequate Screening for Esophageal Varices: Prospective Application of the Baveno Vi Guidelines in 1,510 Cases. 27th Annual Canadian Conference on HIV/AIDS Research (CAHR 2018), Vancouver BC, Canada, conference date: 2018/04
  6. Cocciolillo S, Osikowicz M, Lebouche B, Szabo J, Klein M, Sebastiani G for the LIVEHIV Study Group. Vitamin E as a treatment for severe fatty liver in HIV mono-infected patients (CTN-PT 024). IDIGH Program Research Day 2018, Montreal, Canada, conference date: 2018/04
  7. Cocciolillo S, Palumbo CS, Lebouche B, Ghali P, Deschenes M, Wong P, Klein M, Sebastiani G de la part de le LIVEHIV Study Group. La cirrhose hépatique occulte diagnostiquée par élastographie impulsionnelle à vibration controlée (VCTE) est fréquente et inadéquatement surveillée chez les patients infectés par le VIH: résultats d’un programme de dépistage à grande échelle. La journée des étudiants, Montreal, Canada, conference date: 2017/11
  8. Pembroke T, Deschenes M, Lebouche B, Sewitch M, Ghali P, Wong P, Halme A, Vuille-Lessard E, Pexos C, Klein MB, Sebastiani G. Hepatic Steatosis progresses faster in HIV mono-infected than HIV/HCV coinfected patients and is associated with liver fibrosis. 26th Annual Meeting of the British Association for the Study of the Liver, London UK, conference date: 2017/09.
  9. Benmassaoud A, Lebouche B, Ghali P, Deschenes M, Klein MB, Sebastiani G. Occult liver cirrhosis diagnosed by transient elastography is frequent and under-monitored in HIV-infected patients: results of a large-scale screening program. International AIDS Society, Paris, France, conference date: 2017/07.
  10. Pembroke T, Lebouche B, Routy J-P, Szabo J, Cox J, Pexos C, Klein M, Sebastiani G. Hepatic Steatosis and Fibrosis Diagnosed by Transient Elastography in Canadians living with HIV: Results of a Large-Scale Screening Program. American Association for the Study of Liver Diseases (AASLD) Emerging Trends Conference 2017: Emerging Trends in Non-alcoholic Fatty Liver Disease, Washington, DC, conference date: 2017/04. Note: Recipient of the trainee travel award of AASLD.
  11. Pembroke T, Lebouche B, Routy J-P, Szabo J, Cox J, Pexos C, Klein M, Sebastiani G. Hepatic Steatosis and Fibrosis Diagnosed by Transient Elastography in Canadians living with HIV: Results of a Large-Scale Screening Program. 26th Annual Canadian Conference on HIV/AIDS Research (CAHR), Montreal, Canada, conference date: 2017/04.
  12. Sebastiani G, Lebouche B, Ghali P, Deschenes M, Wong P, Klein M. Prevalence and predictors of occult cirrhosis diagnosed by transient elastography in 1,658 HIV infected patients. 26th Annual Canadian Conference on HIV/AIDS Research (CAHR), Montreal, Canada, conference date: 2017/04. (Oral presentation).
  13. Raynes J, Sebastiani G. Regression of liver fibrosis after successful all oral antiviral therapy in HCV cirrhosis: a pilot study employing transient elastography and Controlled Attenuation Parameter (CAP). Canadian Digestive Diseases Week, Banff, AB, conference date: 2017/03.
  14. Pembroke T, Deschenes M, Ghali P, Wong P, Lebouche B, Routy J-P, Costiniuk C, Klein M, Sebastiani G. Évaluation de la stéatose et la fibrose hépatique chezles Canadiens vivant avec le VIH: Résultat d’un large programme de dépistage utilisantl’élastographie transitoire avec le paramètre d’atténuation contrôlée. Journée des étudiants Reseau SIDA/MI du FRQ-S, Montreal, QC, conference date: 2016/11. (Oral presentation). Note: Recipient of the student prize of the FRQ-S for the best oral presentation.
  15. Benmassaoud A, Deschenes M, Ghali P, Wong P, Lebouche B, Routy J-P, Costiniuk C, Klein M, Sebastiani G. Utilité de la Cytokeratin-18 sérique et de l’élastographie transitoire avec le paramètre d’atténuation contrôlée pour le diagnostic de la stéatohépatite non-alcoolique chez les patients avec le VIH. Journée des étudiants Reseau SIDA/MI du FRQ-S, Montreal, QC, conference date: 2016/11. (Oral presentation).
  16. Benmassaoud A, Deschenes M, Ghali P, Lennox L, Wong P, Klein MB, Sebastiani G. Cytokeratin 18 and Transient Elastography with Controlled Attenuation Parameter as Screening Tools for Nonalcoholic Steatohepatitis in HIV Mono-Infected Patients. 67th annual meeting of the American Association for the Study of Liver Diseases (AASLD) 2016, Boston, US, conference date: 2016/11.
  17. Sebastiani G, Ghali P, Wong P, Lennox L, Deschenes M, Klein MB. Hepatic Steatosis and Fibrosis Diagnosed by Transient Elastography with Controlled Attenuation Parameter in Canadians Living with HIV Receiving Antiretroviral Therapy: Results of a Screening Program of 1033 Patients. 67th annual meeting of the American Association for the Study of Liver Diseases (AASLD), Boston, US, conference date: 2016/11. (Oral presentation).
  18. Dulai P, Singh S, Patel J, Soni M, Younossi Z, Sebastiani G, Ekstedt M, Hagström H, Nasr P, Stal P, Wong V, Kechagias S, Hultcrantz R, Loomba R. Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: Systematic Review and Meta-analysis. 67th annual meeting of the American Association for the Study of Liver Diseases (AASLD) 2016, Boston, US, conference date: 2016/11.
  19. Vuille-Lessard E, Lebouché B, Lennox L, Routy JP, Costiniuk C, Pexos C, Giannakis A, Szabo J, Klein MB, Sebastiani G. Prevalence and cofactors of nonalcoholic fatty liver disease diagnosed by transient elastography with controlled attenuation parameter in HIV mono-infection. International AIDS Conference, 2016, Durban, South Africa, conference date: 2016/7. Note: Recipient of the scholarship of the 21st International AIDS Conference (AIDS 2016), scholarship ID: S23813.
  20. Vuille-Lessard E, Lebouche B, Lennox L, Klein MB, Sebastiani G. NASH diagnosed by serum cytokeratin 18 and transient elastography with controlled attenuation parameter in HIV mono-infected patients on antiretroviral therapy. 25th Annual Canadian Conference on HIV/AIDS Research (CAHR), Winnipeg, Canada, conference date: 2016/05. (Oral presentation). Note: Recipient of the academic scholarship of the Annual Canadian Conference on HIV/AIDS Research.
  21. Sebastiani G, Wagner J, Klein MB and Pantopoulos K. Association of fibroblast growth factor 23 and serum ferritin with liver fibrosis diagnosed by transient elastography in HIV/HCV co−infected patients. 25th Annual Canadian Conference on HIV/AIDS Research (CAHR), Winnipeg, Canada, conference date: 2016/05. (Oral presentation).
  22. Sebastiani G, Lennox L, Pexos C, Costiniuk C, LeBlanc R, Routy J-P, Cox J, Lebouche B, Klein MB. Cytokeratin 18 and transient elastography with controlled attenuation parameter as screening tools for nonalcoholic steatohepatitis in HIV mono-infection. 25th Annual Canadian Conference on HIV/AIDS Research (CAHR), Winnipeg, Canada, conference date: 2016/05.
  23. Vuille-Lessard E, Lennox L, Pexos C, Lebouché B, Klein MB, Sebastiani G. Prevalence and factors associated with Nonalcoholic fatty liver disease as diagnosed by transient elastography with controlled attenuated parameter in HIV mono-infected patients. Canadian Digestive Diseases Week (CCDW) 2016, Montreal, Canada, conference date: 2016/2. (Oral presentation). Note: Recipient of Canadian Association for the Study of the Liver (CASL) Student Research Prize.
  24. Sebastiani G, Lennox L, Pexos C, Lebouché B, Klein MB. Nonalcoholic steatohepatitis diagnosed by the serum biomarker Cytokeratin 18 is frequent in HIV infected patients and is associated with liver fibrosis by transient elastography. Canadian Digestive Diseases Week (CCDW), Montreal, Canada, conference date: 2016/2.
  25. Sebastiani G, Wagner J, Rollet K, Klein M, Pantopoulos K. Serum ferritin and fibroblast growth factor 23 are associated with liver fibrosis diagnosed by transient elastography in HIV/HCV coinfected patients. Bioiron, Hangzhou, China, conference date: 2016/9.

Abstracts and Publications